Researchers have found that people who develop dementia may
start to lose awareness of their memory problems 2 to 3 years before memory
loss or dementia starts.
Dementia is a general term for a decline in memory loss and
cognitive skills with enough severity to interfere with daily life. The most
common form of dementia is Alzheimer’s disease. An estimated 5.3 million
Americans of all ages have Alzheimer’s. It is the sixth leading cause of death
in the United States. According to Alzheimer’s Society UK, the number of
Alzheimer’s patients in UK will reach 850,000 by the end of this year.
The study done by Rush University Medical Center in Chicago
was published in the journal Neurology.
The researchers also found that many memory loss or brain
changes related to dementia, or pathologies are to be blamed for the deterioration
in memory awareness.
Robert S. Wilson, PhD, of Chicago’s Rush University Medical
Center, says that their findings suggest not being aware about one’s memory
problems is an unavoidable characteristic of late-life dementia that is initiated
by an accumulation of changes in the brain that are related to dementia.
Dr. Wilson, who is also a study author added that not being
aware of memory loss is usual in dementia, but they never knew much about its
commonness, when it develops and why some individual appear more affected than
others.
Participants in the memory loss or dementia study were 2,092
adults with an average age of 76 years, who had no signs of memory loss or
cognitive impairment. Researchers monitored the participants for more than 10
years. They had to take yearly tests on memory and cognitive skills. They were
asked how often they found it difficult to remember things and were also told
to assess their memory compared to ten years prior.
During the course of the study, 239 participants were
diagnosed with dementia. In these seniors, awareness of memory problems began
to drop abruptly on an average of 30 months before dementia first appeared.
While results were same for all the participants, researchers were surprised to
find that memory loss occurred earlier in younger participants compared to the
older ones. Researchers believe that this might be because reporting was misrepresented
in older people who usually expect memory loss as a usual part of aging.
Although there were distinct differences in the timing of
the unawareness and the speed of its progression, almost all the people were
unaware about their memory difficulties at any point in the disease, explains
Dr. Wilson.
Brains of 385 subjects who died during the study period were
also examined by the researchers. They assessed these brains for seven types of
brain alterations that are common to dementia. They discovered that three
dementia-related pathologies were linked with the speedy degeneration in memory:
1.
Tau proteins also known as tangles
2.
Infarcts (areas of brain damage)
3.
Changes in the TDP-43 protein
As these changes in the brain build up, people fail to realize
that their memory is declining.
This study highlights the usefulness of loved ones and
family members asking for help from healthcare professionals and doctors
getting information from family or friends during the decision making process
about whether someone has dementia, since those affected by dementia may not be
able to provide decisive information about the case study of their own
cognition, says Dr. Wilson.
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