Saturday, January 13, 2018

Scientists identify vital early warning of Alzheimer’s that could lead to improved treatment

Scientists identify vital early warning of Alzheimers

Scientists made a breakthrough in identifying molecular mechanism by which Alzheimer’s destroys the ability for brain cells to “talk” to each other. The discovery could enable doctors to predict the onset of the disease years in advance, allowing crucial early treatment.

The lead researcher, Dr. Vladimir Sytnyk, from the University of New South Wales (UNSW) School of Biotechnology and Biomolecular Sciences, explains that loss of synapses - which connect brain neurons - is one of the first changes associated with Alzheimer's disease.

Loss of synapses is one of the early signs of the disease. Synapses connect neurons in our brain. Synapses are needed for all brain functions, especially forming memories and learning.


Dr. Sytnyk says that synapses loss occurs in the very early stages of the degenerative disease, long before the nerve cells die, when only mild cognitive impairment is observed.

Alzheimer’s is a fast progressing neurodegenerative disease that starts out slow, but deteriorates over time. Short-term memory loss is the most common early symptom. Alzheimer’s is the most common cause of dementia, accounting for about 60-70% of all dementia cases.

German psychiatrist and pathologist Dr. Alois Alzheimer first discovered the disease in 1906. Dr. Alzheimer’s saw alterations in the post-mortem brain tissue of a woman who died of an unusual mental illness. Upon performing a post-mortem brain examination he found abnormal clumps what we now know as amyloid plaques and neurofibrillary tangles - now called tau tangles.


Considered as the hallmarks of Alzheimer’s disease, these plaques and tangles are believed to cause the death of brain cells, which leads to the disease.

Age is one of the risk factors of Alzheimer’s. People over the age of 70 are at a higher risk of developing Alzheimer’s. Approximately 80 percent of people over the age of 85 are affected by this dreaded disease.

Scientists identify vital early warning of Alzheimers
Short-term memory loss is the most common early symptom (Image credit: Creative commons)

Alzheimer’s has been recently ranked as the third leading cause of death in the United States. An estimated 5.3 million Americans of all ages have Alzheimer’s.

In UK, around 800,000 people are affected by the disease.

Dr. Sytnyk and his team wanted to further examine brain alterations related to Alzheimer’s. They studied a brain protein known as neural cell adhesion molecule 2 (NCAM2) – part of a group of molecules that connect synapse membranes, maintaining the synaptic connections between neurons.


Researchers used brain tissue of dead people with or without the disease. They found that people with Alzheimer’s had low levels of synaptic NCAM2 in their hippocampus.

In the brain of Alzheimer’s patients, most of the damage occurs in the hippocampus of the brain, the area which is essential in forming memories.

Moreover, through mice studies, they discovered that NCAM2 was battered by beta-amyloid. As discussed earlier, bety-amyloid is the main constituent of the plaques that accumulate in the brains of Alzheimer’s patients.

The findings shows that the loss of synapses is related to the loss of NCAM2, caused by toxic effects of beta-amyloid, according to Dr. Sytnyk. He hints that it may open up a new avenue to study treatments that can stop the destruction of NCAM2.


The research team was made up of researchers from Neuroscience Research Australia (NeuRA) and the UNSW School of Medical Sciences’ Dementia Research Unit.

They publish their work the journal Nature Communications.


3 comments:

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