Music may improve memory in dementia patients, study finds

Music is a powerful medium that moves us physically and mentally. It has the power to transport us back to an earlier time or give us a sense of dejavu. Music has always been known to enhance our mood, but a new study reports that music may help preserve and even enhance cognitive function in elderly patients with mild to moderate dementia.

The findings of the study, conducted by researchers from University of Helsinki, Finland, and published in the Journal of Alzheimer's Disease, could lead to better dementia care for the elderly.

Lead author of the study Dr. Teppo Sarkamo, a specialist in cognitive brain research, behavioral science and music research said,

“Our findings suggest that musical leisure activities could be easily applied and widely used in dementia care and rehabilitation.”

For the study, the researchers looked at the effects of musical coachingto 89 patients with mild to moderate dementia when they joined the 10-week intervention along with their caregivers. They were randomly assigned to one of three groups. Factors such as, participants’ age, dementia severity, care situation, and previous musical experience were taken into account.

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The first group of pairs went through 10 weeks of singing, the second group of pairs focused only on listening to music and the third group acted as a control group, which involved standard care only.

Evaluations taken after 9 months into the trial showed that memory, executive function, orientation and mood already improved in the groups receiving musical coaching compared with the control group. Executive function helps us focus attention, plan, remember and manage several tasks at the same time.

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The researchers also discovered that patients with mild dementia and below 80 years old benefited the most for memory, executive function and orientation by singing. For the patients with more advanced form of dementia, music listening led to the most cognitive enhancements.

Furthermore, singing and music listening also relieved depression for patients with mild Alzheimer's-type dementia, compared with the control group receiving standard care.

Another interesting fact noted by the researchers was that the patients’ musical background made no difference in the results.

Researchers advise that patients with dementia shouldengage in musical activities during the early stages of the disorder. Dr. Sarkamo even advises patients that they should be encouraged by their caregivers to sing regularly or join a community choir.

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“Given the increasing global prevalence and burden of dementia and the limited resources in public health care for persons with dementia and their family caregivers, it is important to find alternative ways to maintain and stimulate cognitive, emotional and social well-being in this population.” said Dr. Sarkamo.

“Especially stimulating and engaging activities, such as singing, seem to be very promising for maintaining memory functioning in the early stages of dementia.”

“In the later stages of dementia when the cognitive deficits are more severe, music listening could be a more easily applicable way,” Sarkamo concluded.

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Alzheimer’s memory loss may be reversed by blocking a key enzyme

Targeting an enzyme that interferes with memory-forming processes in Alzheimer’s patients can be an effective treatment for memory loss, according to a new study. A team of scientists from the Massachusetts Institute of Technology (MIT) in the U.S. found that it may be possible to reverse Alzheimer’s related memory loss with drugs that selectively impede the ability of the Histone deacetylase-2 (HDAC2) enzyme to interfere with the communication between brain cells.

Previously, scientists failed to target HDAC2because the drugs that were used also impeded other roles of the enzyme, causing toxic side effects.

The new research has shown that blocking a molecule called sp3 that binds to HDAC2 might effectively stop them both from disrupting the communication between brain cells that is crucial for memory.

"If we can remove the blockade by inhibiting HDAC2 activity or reducing HDAC2 levels," explains Seniorauthor Prof. Li-Huei Tsai, director of the Picower Institute for Learning and Memory at MIT, "then we can remove the blockade and restore expression of all these genes necessary for learning and memory."

For over a decade, Prof. Tsai has been researching the role that enzymes called HDACs play in memory loss. In2007, she discovered that blocking HDAC activity in mice could reverse memory loss. There are around a dozen types of HDAC in humans.

Alzheimer's disease is the most common form of dementia, affecting around 850,000 people in the UK. This neurodegenerative disease gradually diminishes a person’s ability to remember, think, reason, and make decisions.

There is no cure for thedisease and scientists do not know the causes of the disease. It is more common among people over 60 years, but it can affect younger people as well.

The new study focuses on the disruption of a process called synaptic plasticity, which is thought to be crucial for memory and learning.

Research has revealed that synapses – the connections between brain cells – are "plastic" and are not fixed as the soldered joints in electronic circuits.

Scientists define synaptic plasticity as a biological process whereby synapses change over time, depending on specific patterns of activity.

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Scientists previously tested compounds that inhibit HDAC2, but most these produced side effects, such as interfering with HDAC1. HDAC1 is crucial for cell proliferation, especially in red and white blood cells.

Therefore, in this new study, Prof. Tsai and his team sought to find a way to target only the HDAC2 activity that impedes memory. The team searched for proteins that help the enzyme to bind to the relevant genes.

To find the diabolical pairing, the researchers examined the expression of genes in postmortem brain samples taken from people who didn’t have Alzheimer’s.

Of these samples some brains had high and some had low levels of HDAC2, which helped the researchers to identify more than 2,000 genes that might be involved with HDAC2 activity.

Next, a technique called gene knockdown was used to prevent the expression of HDAC2 and other genes in mice. This narrowed down the search to a gene that made the protein Sp3.

Fragments of HDAC2 were used to connect with Sp3 in the mice. This effectively mopped up the proteins and prevented them from forming a complex with complete HDAC2 enzymes.

This clean-up was useful and it helped restore mice’s nerve functions, providing evidence that the enzyme and its helper were both required to latch onto the histones and DNA and prevent them from working.

The study was published in the journal Cell Reports.

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Does Memory Loss Always Mean Dementia?

Dementia or senility isn’t a specific disease. Instead, it is a broad category of symptoms that affect the brain and causes memory loss. The loss of memory affects social abilities and cognitive skills that are severe enough to interfere with daily life.

The most common form of dementia is Alzheimer’s disease, which accounts for 60%-80% of all dementia cases. Other common types of dementia include vascular dementia – accounting for 25%, Lewy body dementia – accounting for 15% and frontotemporal dementia. A person can be affected by more than one type of dementia.

Every 3 seconds, someone in the world develops dementia. There were an estimated 46.8 million people worldwide living with dementia in 2015 and this number is believed to be close to 50 million people in 2017. 5.2% of people over the age of 60 are living with dementia globally. The number of people with dementia will almost double every 20 years, reaching 75 million in 2030 and 131.5 million in 2050. Developing countries will see much of theincrease. Currently, around 58% of people with dementia live in low- and middle-income countries, but this will rise to 68% by 2050. The fastest growth in the elderly population is taking place in China, India, and their south Asian and western Pacific neighbors.

There are about 5.7 million people of all ages are affected with Alzheimer’s disease in the USA. Almost two thirds of Americans with Alzheimer’s are women.

According to Alzheimer’s Society, UK, an estimated 850,000 people are affected by dementia in the UK, with the number expected to rise to over 1 million by 2025. It is expected that 225,000 people will develop dementia this year that is 1 person every 3 minutes.

Does Memory Loss Mean A Person Has Dementia?

Although loss of memory usually occurs in dementia, loss of memory alone does not mean a person has dementia. People lose some degree of memory as they get older. Naturally occurring memory loss isn’t considered dementia. At least 2 of thefollowing cognitive functions must be significantly damaged to be considered dementia:

1. Loss of memory
2. Problem communicating or understanding language
3. Inability to focus
4. Inability to make decisions or judgments
5. Lack of visual perception

What are the Types of Dementia?

The different types of dementia include:

• Alzheimer’s disease. It is the most common for of dementia, accounting for 60 to 80 percent of all dementia cases. Alzheimer’s causes problems with memory, thinking and behavior.
• Vascular dementia. It is the second most common type of dementia, which occurs after a stroke.
• Dementia with Lewy Bodies (DLB). It is a form of progressive dementia that leads to a decline in thinking, reasoning and independent function due to abnormal microscopic deposits that damage brain cells over time.
• Parkinson’s disease dementia. It is a cognitive impairment that ultimately affects many people with Parkinson's disease.
• Mixed dementia. In this type of dementia, abnormal characteristics of more than one type of dementia occur simultaneously.
• Frontotemporal dementia (FTD). It is a group of disorders caused by progressive nerve cell loss in the brain's frontal lobes (the areas behind the forehead) or its temporal lobes (the regions behind the ears).
• Huntington’s disease. It is a progressive brain disorder caused by a defective gene. This disease causes changes in the central area of the brain, which affect movement, mood and thinking skills.
• Creutzfeldt-Jakob disease (CJD). It is the most common human form of a group of rare, fatal brain disorders known as prion diseases.
• Normal pressure hydrocephalus (NPH). It is a brain disorder in which excess cerebrospinal fluid accumulates in the brain's ventricle, causing thinking and reasoning problems, difficulty walking, and loss of bladder control.
• Wernicke-Korsakoff Syndrome. It is a chronic memory disorder caused by severe deficiency of thiamine (vitamin B-1). Korsakoff syndrome is most commonly caused by alcohol misuse, but certain other conditions also can cause the syndrome.
• Posterior cortical atrophy (PCA). It is the gradual and progressive degeneration of the outer layer of the brain (the cortex) in the part of the brain located in the back of the head (posterior).

Are there Warning Signs One Should Watch Out For?

What Are the Stages of Dementia?

Dementia may have several stages such as, mild, moderate or severe. A dementia patient may fall into 2 different stages at once. Progression of a patient’s condition cannot be determined by the stages of dementia. A patient may remain in a particular stage for a few months or a several years. Progression of the disease varies in patient to patient.

What Are the Causes of Dementia?

Death of the nerve cells in the brain causes dementia. Dementia may be caused by head injury, stroke or a brain tumor. Since, death of brain cells may occur in different parts of the brain, dementia’s affect on people may vary from person to person.

What Are the Signs and symptoms of Dementia?

Dementia, in its early stage may have signs like forgetting things, difficulty performing tasks that were previously done without effort, losing common items such as keys, glasses etc. Difficulty learning new things is a very common early sign of dementia. Many Alzheimer’s patients or patients with other forms of dementia are unaware about their problems. The behavioral changes become evident with the progression of the disease. Patients fail to perform simple tasks, such as putting on clothes or going to the bathroom. Some patients may forget their phone numbers, addresses or their date of birth. They may be unaware about their surrounding environment. Some patients may forget to take their food, which may lead to marked weight loss. At the late stages of dementia, patients often cannot recognize their friends or family members. They lose their ability to communicate effectively. They become unable to care for themselves and need help of others to perform daily activities. As the disease progresses, patients start to forget how to walk or how to get up from a chair.

Can Dementia Be Reversed?

Doctors may identify the causes of certain dementia, therefore conditions can be reversed with proper treatment.

• When dementia-like conditions occur from fever or other infections such as meningitis, encephalitis, syphilis, Lyme disease. Dementia from immune disorders such as leukemia and multiple sclerosis can also be reversed.
• Dementia from metabolic problems and abnormalities of endocrine.
• When nutritional deficiencies cause dementia.
• When dementia is caused by poisoning.
• Subdural hematomas
• Rarely, brain tumors can cause dementia
• Reactions to medication

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Repeating words aloud to another boosts memory recall

You should read this if you are preparing for your exams, trying to memorize a speech or just trying to boost memory recall. A new study has found that repeating words aloud to another person can increase your verbal memory. Victor Boucher, a professor in the Department of Linguistics and Translation at University of Montreal said that the results of his study will be published in the next edition of the journal Consciousness and Cognition.

“We knew that repeating aloud was good for memory, but this is the first study to show that if it is done in a context of communication, the effect is greater in terms of information recall,” explained prof. Boucher. [Read more Eating fish weekly makes kids more intelligent and sleep better]

To demonstrate their findings on how to boost memory, Boucher and Alexis Lafleur, a doctoral student in neuropsychology asked 44 French-speaking university students to participate in a series of tasks.

For the first test, the participants were asked to read a number of lexemes from a computer screen. Lexemes are words written as they are found in the dictionary. During each stage of the test to boost memory, participants had to wear headphones that emitted “white noise.” This mechanism would mask their voices and thereby avoid auditory feedback.

For the next stage, participants were asked to repeat the words in 4 experimental conditions – repeat the words in their mind, repeat them silently by moving their lips, repeat the words aloud while staring at the screen and repeat the words aloud to another person. [Read more Learning foreign languages may sharpen our minds]

In the final stage of the test to boost memory recall, participants were made to engage in distraction task. After the completion of distraction task, they were shown another list of lexemes – some of which were shown to them before and some of which were not.

The results showed that performing the exercise aloud produced the highest verbal memory recall, while the least effective way to recall information was by repeating the lexemes in one’s head without gesturing.

According to Prof. Boucher, the simple way of communicating without making any sound generates a sensorimotor link that boosts our means to remember. But, we remember even more if the procedure is associated with the functionality of speech.

Another set of experiment was conducted in the test to boost memory recall. In this, the students were asked to repeat “non-words,” or chains of syllables that are not part of lexemes, in each of the four conditions mentioned before. [মধুর যত মধুর গুণাবলী]

The results showed that the students, repeating the non-words aloud to another did not show any higher verbal memory recall than repeating them in any of the other conditions. Boucher explains this as the brain’s inability to associate non-words with verbal memory. He noted that previous studies done by his team showed that the eloquence of a sound leaves a sensory and motor mark in the brain.

Boucher concluded by saying that a more coherent recall of the verbal element is created by the production of one or more sensory aspects. When talking to someone, aspects of sensorimotor and verbal expression are added to the brain’s multisensory information associated with the communication episode. Because of this, information is better retained in memory which shows that repeating words aloud to another person boosts memory recall.

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